abstract：:During infection Neisseria meningitidis (Nm) encounters multiple environments within the host, which makes rapid adaptation a crucial factor for meningococcal survival. Despite the importance of invasion into the bloodstream in the meningococcal disease process, little is known about how Nm adapts to permit survival a...

journal_title：PLoS pathogens

authors： Echenique-Rivera H,Muzzi A,Del Tordello E,Seib KL,Francois P,Rappuoli R,Pizza M,Serruto D

更新日期：2011-05-01 00:00:00

abstract：:Helicobacter pylori (Hp) injects the CagA effector protein into host epithelial cells and induces growth factor-like signaling, perturbs cell-cell junctions, and alters host cell polarity. This enables Hp to grow as microcolonies adhered to the host cell surface even in conditions that do not support growth of free-sw...

journal_title：PLoS pathogens

authors： Tan S,Noto JM,Romero-Gallo J,Peek RM Jr,Amieva MR

更新日期：2011-05-01 00:00:00

abstract：:Many animal and plant viruses rely on vectors for their transmission from host to host. Grapevine fanleaf virus (GFLV), a picorna-like virus from plants, is transmitted specifically by the ectoparasitic nematode Xiphinema index. The icosahedral capsid of GFLV, which consists of 60 identical coat protein subunits (CP),...

journal_title：PLoS pathogens

authors： Schellenberger P,Sauter C,Lorber B,Bron P,Trapani S,Bergdoll M,Marmonier A,Schmitt-Keichinger C,Lemaire O,Demangeat G,Ritzenthaler C

更新日期：2011-05-01 00:00:00

abstract：:SIV(mac239) infection of rhesus macaques (RMs) results in AIDS despite the generation of a strong antiviral cytotoxic T lymphocyte (CTL) response, possibly due to the emergence of viral escape mutants that prevent recognition of infected cells by CTLs. To determine the anatomic origin of these SIV mutants, we longitud...

journal_title：PLoS pathogens

authors： Vanderford TH,Bleckwehl C,Engram JC,Dunham RM,Klatt NR,Feinberg MB,Garber DA,Betts MR,Silvestri G

更新日期：2011-05-01 00:00:00

abstract：:Kaposi's sarcoma (KS) lesions are complex mixtures of KS-associated herpesvirus (KSHV)-infected spindle and inflammatory cells. In order to survive the host immune responses, KSHV encodes a number of immunomodulatory proteins, including the E3 ubiquitin ligase K5. In exploring the role of this viral protein in monocyt...

journal_title：PLoS pathogens

authors： Karki R,Lang SM,Means RE

更新日期：2011-04-01 00:00:00

abstract：:Staphylococcus aureus is a major human pathogen causing a wide spectrum of nosocomial and community-associated infections with high morbidity and mortality. S. aureus generates a large number of virulence factors whose timing and expression levels are precisely tuned by regulatory proteins and RNAs. The aptitude of ba...

journal_title：PLoS pathogens

authors： Felden B,Vandenesch F,Bouloc P,Romby P

更新日期：2011-03-01 00:00:00

abstract：:Malaria parasites must undergo a round of sexual reproduction in the blood meal of a mosquito vector to be transmitted between hosts. Developing a transmission-blocking intervention to prevent parasites from mating is a major goal of biomedicine, but its effectiveness could be compromised if parasites can compensate b...

journal_title：PLoS pathogens

authors： Ramiro RS,Alpedrinha J,Carter L,Gardner A,Reece SE

更新日期：2011-03-01 00:00:00

abstract：:After entry into target cells, retroviruses encounter the host restriction factors such as Fv1 and TRIM5α. While it is clear that these factors target retrovirus capsid proteins (CA), recognition remains poorly defined in the absence of structural information. To better understand the binding interaction between TRIM5...

journal_title：PLoS pathogens

authors： Ohkura S,Goldstone DC,Yap MW,Holden-Dye K,Taylor IA,Stoye JP

更新日期：2011-03-01 00:00:00

abstract：:Growing experimental evidence indicates that, in addition to the physical virion components, the non-structural proteins of hepatitis C virus (HCV) are intimately involved in orchestrating morphogenesis. Since it is dispensable for HCV RNA replication, the non-structural viral protein NS2 is suggested to play a centra...

journal_title：PLoS pathogens

authors： Popescu CI,Callens N,Trinel D,Roingeard P,Moradpour D,Descamps V,Duverlie G,Penin F,Héliot L,Rouillé Y,Dubuisson J

更新日期：2011-02-10 00:00:00

abstract：:The herpesviruses, like most other DNA viruses, replicate in the host cell nucleus. Subnuclear domains known as promyelocytic leukemia protein nuclear bodies (PML-NBs), or ND10 bodies, have been implicated in restricting early herpesviral gene expression. These viruses have evolved countermeasures to disperse PML-NBs,...

journal_title：PLoS pathogens

authors： Reichelt M,Wang L,Sommer M,Perrino J,Nour AM,Sen N,Baiker A,Zerboni L,Arvin AM

更新日期：2011-02-03 00:00:00

abstract：:Ingested Vibrio cholerae pass through the stomach and colonize the small intestines of its host. Here, we show that V. cholerae requires at least two types of DNA repair systems to efficiently compete for colonization of the infant mouse intestine. These results show that V. cholerae experiences increased DNA damage i...

journal_title：PLoS pathogens

authors： Davies BW,Bogard RW,Dupes NM,Gerstenfeld TA,Simmons LA,Mekalanos JJ

更新日期：2011-02-01 00:00:00

abstract：:The prevalence of antibiotic resistance genes in pathogenic bacteria is a major challenge to treating many infectious diseases. The spread of these genes is driven by the strong selection imposed by the use of antibacterial drugs. However, in the absence of drug selection, antibiotic resistance genes impose a fitness ...

journal_title：PLoS pathogens

authors： Albarracín Orio AG,Piñas GE,Cortes PR,Cian MB,Echenique J

更新日期：2011-02-01 00:00:00

abstract：:The progression of a natural bacterial infection is a dynamic process influenced by the physiological characteristics of the target organ. Recent developments in live animal imaging allow for the study of the dynamic microbe-host interplay in real-time as the infection progresses within an organ of a live host. Here w...

journal_title：PLoS pathogens

authors： Melican K,Sandoval RM,Kader A,Josefsson L,Tanner GA,Molitoris BA,Richter-Dahlfors A

更新日期：2011-02-01 00:00:00

abstract：:The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1. Here, we show that lysosomal membrane permeabilization (LMP) and cytosolic translocation of activated cathepsin D occur prior to activation of a mitochondrial pat...

journal_title：PLoS pathogens

authors： Bewley MA,Marriott HM,Tulone C,Francis SE,Mitchell TJ,Read RC,Chain B,Kroemer G,Whyte MK,Dockrell DH

更新日期：2011-01-27 00:00:00

abstract：:Intracellular parasites, such as Leishmania spp, must acquire suitable carbon sources from the host cell in order to replicate. Here we present evidence that intracellular amastigote stages of Leishmania exploit amino sugars in the phagolysosome of mammalian macrophages as a source of carbon and energy. L. major paras...

journal_title：PLoS pathogens

authors： Naderer T,Heng J,McConville MJ

更新日期：2010-12-23 00:00:00

abstract：:Malaria, caused by the apicomplexan parasite Plasmodium, still represents a major threat to human health and welfare and leads to about one million human deaths annually. Plasmodium is a rapidly multiplying unicellular organism undergoing a complex developmental cycle in man and mosquito - a life style that requires r...

journal_title：PLoS pathogens

authors： Kehr S,Sturm N,Rahlfs S,Przyborski JM,Becker K

更新日期：2010-12-23 00:00:00

abstract：:Despite a high current standard of care in antiretroviral therapy for HIV, multidrug-resistant strains continue to emerge, underscoring the need for additional novel mechanism inhibitors that will offer expanded therapeutic options in the clinic. We report a new class of small molecule antiretroviral compounds that di...

journal_title：PLoS pathogens

authors： Blair WS,Pickford C,Irving SL,Brown DG,Anderson M,Bazin R,Cao J,Ciaramella G,Isaacson J,Jackson L,Hunt R,Kjerrstrom A,Nieman JA,Patick AK,Perros M,Scott AD,Whitby K,Wu H,Butler SL

更新日期：2010-12-09 00:00:00

abstract：:CD4(+) T cells are essential for the control of Yersinia enterocolitica (Ye) infection in mice. Ye can inhibit dendritic cell (DC) antigen uptake and degradation, maturation and subsequently T-cell activation in vitro. Here we investigated the effects of Ye infection on splenic DCs and T-cell proliferation in an exper...

journal_title：PLoS pathogens

authors： Autenrieth SE,Linzer TR,Hiller C,Keller B,Warnke P,Köberle M,Bohn E,Biedermann T,Bühring HJ,Hämmerling GJ,Rammensee HG,Autenrieth IB

更新日期：2010-11-24 00:00:00

abstract：:HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious virion requires proteolytic cleavage of the Gag polyprotein at five positions, leading to a dramatic change in virus morphology. Immature virions contain an incomplete spherical shell where Gag is arranged with the N-term...

journal_title：PLoS pathogens

authors： de Marco A,Müller B,Glass B,Riches JD,Kräusslich HG,Briggs JA

更新日期：2010-11-24 00:00:00

abstract：:The human monoclonal antibody (mAb) HK20 neutralizes a broad spectrum of primary HIV-1 isolates by targeting the highly conserved heptad repeat 1 (HR1) of gp41, which is transiently exposed during HIV-1 entry. Here we present the crystal structure of the HK20 Fab in complex with a gp41 mimetic 5-Helix at 2.3 Å resolut...

journal_title：PLoS pathogens

authors： Sabin C,Corti D,Buzon V,Seaman MS,Lutje Hulsik D,Hinz A,Vanzetta F,Agatic G,Silacci C,Mainetti L,Scarlatti G,Sallusto F,Weiss R,Lanzavecchia A,Weissenhorn W

更新日期：2010-11-18 00:00:00

abstract：:Paramyxoviruses are known to replicate in the cytoplasm and bud from the plasma membrane. Matrix is the major structural protein in paramyxoviruses that mediates viral assembly and budding. Curiously, the matrix proteins of a few paramyxoviruses have been found in the nucleus, although the biological function associat...

journal_title：PLoS pathogens

authors： Wang YE,Park A,Lake M,Pentecost M,Torres B,Yun TE,Wolf MC,Holbrook MR,Freiberg AN,Lee B

更新日期：2010-11-11 00:00:00

abstract：:The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. We investigated the roles of each pattern recognition receptor in rhinovirus infection using primary bronchial epithelial cells. TLR3 was constitutively expressed; however, RIG-I and M...

journal_title：PLoS pathogens

authors： Slater L,Bartlett NW,Haas JJ,Zhu J,Message SD,Walton RP,Sykes A,Dahdaleh S,Clarke DL,Belvisi MG,Kon OM,Fujita T,Jeffery PK,Johnston SL,Edwards MR

更新日期：2010-11-04 00:00:00

abstract：:The SUPPRESSOR OF rps4-RLD1 (SRFR1) gene was identified based on enhanced AvrRps4-triggered resistance in the naturally susceptible Arabidopsis accession RLD. No other phenotypic effects were recorded, and the extent of SRFR1 involvement in regulating effector-triggered immunity was unknown. Here we show that mutation...

journal_title：PLoS pathogens

authors： Kim SH,Gao F,Bhattacharjee S,Adiasor JA,Nam JC,Gassmann W

更新日期：2010-11-04 00:00:00

abstract：:RNA interference (RNAi) pathways are widespread in metaozoans but the genes required show variable occurrence or activity in eukaryotic microbes, including many pathogens. While some Leishmania lack RNAi activity and Argonaute or Dicer genes, we show that Leishmania braziliensis and other species within the Leishmania...

journal_title：PLoS pathogens

authors： Lye LF,Owens K,Shi H,Murta SM,Vieira AC,Turco SJ,Tschudi C,Ullu E,Beverley SM

更新日期：2010-10-28 00:00:00

abstract：:The host response to mycobacterial infection depends on host and pathogen genetic factors. Recent studies in human populations suggest a strain specific genetic control of tuberculosis. To test for mycobacterial-strain specific genetic control of susceptibility to infection under highly controlled experimental conditi...

journal_title：PLoS pathogens

authors： Di Pietrantonio T,Hernandez C,Girard M,Verville A,Orlova M,Belley A,Behr MA,Loredo-Osti JC,Schurr E

更新日期：2010-10-28 00:00:00

abstract：:Micro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability. Recently, a number of viruses, particularly of the herpesvirus family, have been shown to express their own miRNAs to control both viral a...

journal_title：PLoS pathogens

authors： Dölken L,Krmpotic A,Kothe S,Tuddenham L,Tanguy M,Marcinowski L,Ruzsics Z,Elefant N,Altuvia Y,Margalit H,Koszinowski UH,Jonjic S,Pfeffer S

更新日期：2010-10-14 00:00:00

abstract：:Certain pathogens deliver effectors into plant cells to modify host protein targets and thereby suppress immunity. These target modifications can be detected by intracellular immune receptors, or Resistance (R) proteins, that trigger strong immune responses including localized host cell death. The accelerated cell dea...

journal_title：PLoS pathogens

authors： Palma K,Thorgrimsen S,Malinovsky FG,Fiil BK,Nielsen HB,Brodersen P,Hofius D,Petersen M,Mundy J

更新日期：2010-10-07 00:00:00

abstract：:Since the advent of genome-wide small interfering RNA screening, large numbers of cellular cofactors important for viral infection have been discovered at a rapid pace, but the viral targets and the mechanism of action for many of these cofactors remain undefined. One such cofactor is cyclophilin A (CyPA), upon which ...

journal_title：PLoS pathogens

authors： Yang F,Robotham JM,Grise H,Frausto S,Madan V,Zayas M,Bartenschlager R,Robinson M,Greenstein AE,Nag A,Logan TM,Bienkiewicz E,Tang H

更新日期：2010-09-23 00:00:00

abstract：:Recombination, complementation and competition profoundly influence virus evolution and epidemiology. Since viruses are intracellular parasites, the basic parameter determining the potential for such interactions is the multiplicity of cellular infection (cellular MOI), i.e. the number of viral genome units that effec...

journal_title：PLoS pathogens

authors： Gutiérrez S,Yvon M,Thébaud G,Monsion B,Michalakis Y,Blanc S

更新日期：2010-09-16 00:00:00

abstract：:The ability of the tubercle bacillus to arrest phagosome maturation is considered one major mechanism that allows its survival within host macrophages. To identify mycobacterial genes involved in this process, we developed a high throughput phenotypic cell-based assay enabling individual sub-cellular analysis of over ...

journal_title：PLoS pathogens

authors： Brodin P,Poquet Y,Levillain F,Peguillet I,Larrouy-Maumus G,Gilleron M,Ewann F,Christophe T,Fenistein D,Jang J,Jang MS,Park SJ,Rauzier J,Carralot JP,Shrimpton R,Genovesio A,Gonzalo-Asensio JA,Puzo G,Martin C,Brosch R

更新日期：2010-09-09 00:00:00

abstract：:Viruses have evolved several strategies to modify cellular processes and evade the immune response in order to successfully infect, replicate, and persist in the host. By utilizing in-silico testing of a transmembrane sequence library derived from virus protein sequences, we have pin-pointed a nine amino-acid motif sh...

journal_title：PLoS pathogens

authors： Cohen T,Cohen SJ,Antonovsky N,Cohen IR,Shai Y

更新日期：2010-09-02 00:00:00

abstract：:Resistance of viruses to mutagenic agents is an important problem for the development of lethal mutagenesis as an antiviral strategy. Previous studies with RNA viruses have documented that resistance to the mutagenic nucleoside analogue ribavirin (1-β-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide) is mediated by am...

journal_title：PLoS pathogens

authors： Agudo R,Ferrer-Orta C,Arias A,de la Higuera I,Perales C,Pérez-Luque R,Verdaguer N,Domingo E

更新日期：2010-08-26 00:00:00

abstract：:Bacteria that live in the environment have evolved pathways specialized to defend against eukaryotic organisms or other bacteria. In this manuscript, we systematically examined the role of the five type VI secretion systems (T6SSs) of Burkholderia thailandensis (B. thai) in eukaryotic and bacterial cell interactions. ...

journal_title：PLoS pathogens

authors： Schwarz S,West TE,Boyer F,Chiang WC,Carl MA,Hood RD,Rohmer L,Tolker-Nielsen T,Skerrett SJ,Mougous JD

更新日期：2010-08-26 00:00:00

abstract：:Herpesviruses infect most humans. Their infections can be associated with pathological conditions and significant changes in T cell repertoire but evidences of symbiotic effects of herpesvirus latency have never been demonstrated. We tested the hypothesis that HCMV and EBV-specific CD8 T cells contribute to the hetero...

journal_title：PLoS pathogens

authors： Sandalova E,Laccabue D,Boni C,Tan AT,Fink K,Ooi EE,Chua R,Shafaeddin Schreve B,Ferrari C,Bertoletti A

更新日期：2010-08-19 00:00:00

abstract：:The Pneumococcal serine-rich repeat protein (PsrP) is a pathogenicity island encoded adhesin that has been positively correlated with the ability of Streptococcus pneumoniae to cause invasive disease. Previous studies have shown that PsrP mediates bacterial attachment to Keratin 10 (K10) on the surface of lung cells t...

journal_title：PLoS pathogens

authors： Sanchez CJ,Shivshankar P,Stol K,Trakhtenbroit S,Sullam PM,Sauer K,Hermans PW,Orihuela CJ

更新日期：2010-08-12 00:00:00

abstract：:As with many viruses, rabies virus (RABV) infection induces type I interferon (IFN) production within the infected host cells. However, RABV has evolved mechanisms by which to inhibit IFN production in order to sustain infection. Here we show that RABV infection of dendritic cells (DC) induces potent type I IFN produc...

journal_title：PLoS pathogens

authors： Faul EJ,Wanjalla CN,Suthar MS,Gale M,Wirblich C,Schnell MJ

更新日期：2010-07-22 00:00:00

abstract：:RNA silencing is an evolutionarily conserved sequence-specific gene-inactivation system that also functions as an antiviral mechanism in higher plants and insects. To overcome antiviral RNA silencing, viruses express silencing-suppressor proteins. These viral proteins can target one or more key points in the silencing...

journal_title：PLoS pathogens

authors： Giner A,Lakatos L,García-Chapa M,López-Moya JJ,Burgyán J

更新日期：2010-07-15 00:00:00

abstract：:Salmonella enterica serovar Typhimurium is a Gram-negative bacterial pathogen causing gastroenteritis in humans and a systemic typhoid-like illness in mice. The capacity of Salmonella to cause diseases relies on the establishment of its intracellular replication niche, a membrane-bound compartment named the Salmonella...

journal_title：PLoS pathogens

authors： Schroeder N,Henry T,de Chastellier C,Zhao W,Guilhon AA,Gorvel JP,Méresse S

更新日期：2010-07-15 00:00:00

abstract：:CD4(+) T cell loss is central to HIV pathogenesis. In the initial weeks post-infection, the great majority of dying cells are uninfected CD4(+) T cells. We previously showed that the 3S motif of HIV-1 gp41 induces surface expression of NKp44L, a cellular ligand for an activating NK receptor, on uninfected bystander CD...

journal_title：PLoS pathogens

authors： Fausther-Bovendo H,Vieillard V,Sagan S,Bismuth G,Debré P

更新日期：2010-07-01 00:00:00

abstract：:Entry of Staphylococcus aureus into the bloodstream can lead to metastatic abscess formation and infective endocarditis. Crucial to the development of both these conditions is the interaction of S. aureus with endothelial cells. In vivo and in vitro studies have shown that the staphylococcal invasin FnBPA triggers bac...

journal_title：PLoS pathogens

authors： Edwards AM,Potts JR,Josefsson E,Massey RC

更新日期：2010-06-24 00:00:00